The Package, as refered to in chapters 20, 21 and 22 is unknown at this time, but it is suspected to be HIV/AIDS
It turns out that the package originated from Chuck who had slept with Rufus and maybe even James.Therefore Rufus may have been infected spread it to his wife Cathy who spread it to Sylvester to Gwendolyn. James slept with Gwendolyn but used a condom although she slept with Sylvester who may have contracted it from Cathy and got it herself. James may have spread it to his wife and she may have spread it to Big man. It is currently unknown who may have it or not.